Retraction Note: Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
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L-type calcium channels and calcium/calmodulin-dependent kinase II differentially mediate behaviors associated with nicotine withdrawal in mice.
Smoking is a widespread health problem. Because the nicotine withdrawal syndrome is a major contributor to continued smoking and relapse, it is important to understand the molecular and behavioral mechanisms of nicotine withdrawal to generate more effective smoking cessation therapies. Studies suggest a role for calcium-dependent mechanisms, such as L-type calcium channels and calcium/calmoduli...
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Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...
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Elevated intracellular Ca2+ triggers inactivation of L-type calcium channels, providing negative Ca2+ feedback in many cells. Ca2+ binding to the main alpha1c channel subunit has been widely proposed to initiate such Ca2+ -dependent inactivation. Here, we find that overexpression of mutant, Ca2+ -insensitive calmodulin (CaM) ablates Ca2+ -dependent inactivation in a "dominant-negative" manner. ...
متن کاملCalcium/calmodulin-dependent protein kinase II.
There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from other tissues appear to behave in a broadl...
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Introduction: Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence. Methods: In the present study, morphine tolerance was induced in male Wistar rats by 7 days repeated morphine injections once daily, and then gene expression profile of α-isoform of CaMKII (CaMKIIα) in the hipp...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2015
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb3151